DRIVER-CLEAN / IMMUNE-SENSITIVE BRCA/HRD · PARP Sensitivity BRCA1/2 / HRD / TP53 / CCNE1 γ₁ = 14.134725141734693 · HGSOC · BRCA1/2 · PARP · HRD · platinum · CA-125 CANCER BOARD NEURO
OVARIAN · HIGH-GRADE SEROUS
Driver
BRCA1/2 / HRD / TP53 / CCNE1
Coverage
~12/100k · High recurrence rate
Confidence
STRONG
Open Sorries
⚠ Platinum resistance at 3rd line
⚠ PARP inhibitor resistance via BRCA reversion
⚠ No immunotherapy signal in MSS
HYPOTHESIS
BRCA-mut → olaparib/niraparib maintenance. HRD+ → PARP-i extends PFS. Platinum-sensitive → re-challenge.
⚠ OPEN: PARP resistance via BRCA reversion — no reliable 3L pathway
3Sorries
γ₁14.134725141734693
CATAN CANCER · OVARIAN