DRIVER-CLEAN / TARGETABLE Ph+/Ph-like/T-ALL · High Cure Rate Pediatric BCR-ABL1 (Ph+) / Ph-like / ETV6-RUNX1 / T-ALL γ₁ = 14.134725141734693 · ALL · BCR-ABL · Ph+ · CAR-T · TKI · MRD CANCER BOARD NEURO
ALL · ACUTE LYMPHOBLASTIC
Driver
BCR-ABL1 (Ph+) / Ph-like / ETV6-RUNX1 / T-ALL
Coverage
~1.7/100k adult · Pediatric cure rate ~90%
Confidence
PROVEN
Open Sorries
⚠ Ph-like ALL — heterogeneous drivers
⚠ T-ALL relapse — no salvage standard
⚠ CNS sanctuary relapse
HYPOTHESIS
Ph+ → TKI+chemo (imatinib/dasatinib). B-ALL relapse → blinatumomab/inotuzumab/CAR-T. Pediatric MRD-guided therapy.
⚠ OPEN: Ph-like ALL — >15 driver subtypes, no unified targeted protocol
3Sorries
γ₁14.134725141734693
CATAN CANCER · BLOOD-ALL